Author(s): L. -L. Gong, D. W. -C. Li, Y. -Z. Liu, W. -B. Liu, Z. -G. Chen, T. -H. Yang, R. -L. Qi, S. Huang, L. Zhang, L. Wang, W. -F. Hu, X. -H. Hu, W. -K. Ji, Z. -F. Wang, Q. Nie, Z. -X. Huang, X. -D. Gong and Y. Yang
Page: [944 - 951] Pages: 8
* (Excluding Mailing and Handling)
The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.
Keywords: Serine/threonine phosphatases-1 and -2A, eye development, lens differentiation, developmental apoptosis.
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