Nano-Hydroxyapatite Doped with Ho-166 as Drug Delivery System for Bone Cancer Therapy and Diagnosis: Developing a Theragnostic Radiopharmaceuticals

Franciana   Maria Rosa da   Silva; Julio   Cezar de   Almeida; Elizabeth   Eugenio de Mello   Oliveira; Marta   de Souza   Albernaz; Alexandre   Malta   Rossi; Ralph      Santos-Oliveira

Anti-Cancer Agents in Medicinal Chemistry

Author(s): Franciana Maria Rosa da Silva, Julio Cezar de Almeida, Elizabeth Eugenio de Mello Oliveira, Marta de Souza Albernaz, Alexandre Malta Rossi and Ralph Santos-Oliveira

DOI: 10.2174/1871520616666151110130428

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Nano-Hydroxyapatite Doped with Ho-166 as Drug Delivery System for Bone Cancer Therapy and Diagnosis: Developing a Theragnostic Radiopharmaceuticals

Page: [355 - 358] Pages: 4

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Abstract

Background: The use of nanobiomaterials is increasing each day. Among the immense variety of nanomaterials developed and studied the hydroxyapatite is one of the most ones.

Objective: In this study we developed and tested nano-hydroxyapatite dopped with Ho-166 for bone cancer.

Results: The results showed that the nano-hydroxyapatite dopped with Ho-166 has a great affinity for the bone.

Conclusion: The pre-clinical studies support the use as a nano-radiopharmaceuticals for bone cancer treatment and diagnosis.

Keywords: Radiopharmaceuticals, nanotechnology, oncology, scanning electron microscopy, transmission electron microscopy.

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