Author(s): Laszlo Orfi, Frigyes Waczek, Janos Pato, Istvan Varga, Balint Hegymegi-Barakonyi, Richard A. Houghten and Gyorgy Ker
Page: [2549 - 2553] Pages: 5
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Purine bases and their bioisosteric analogs are widely used as building blocks in combinatorial chemistry. Recently a great number of fused pyrimidine derivatives became known as potential drug molecules against various types of proliferative diseases, caused by over-expression of protein kinases [1]. One of the most important compound
Keywords: pyrimidines, quinazolin-4-ones, formamidine-acetate, imidoyl-chlorides, purine analogs, protein kinase inhibitors, antiproliferative agents, phosphodiesterase v inhibitors
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