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Letters in Organic Chemistry

Author(s): Fan Wang, Xiao-Ying Xu, Fei-Ying Wang, Lin Peng, Yong Zhang, Liang-Liang Wang and Li-Xin Wang

DOI: 10.2174/1570178612666150907204813

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An Efficient and Improved Process for the Scale-up Preparation of cis- Cyclopropanediamine Dihydrochloride

Page: [741 - 744] Pages: 4

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Abstract

An effective and improved process for the preparation of cis-cyclopro panediamine dihydrochloride was developed in a 100 g scale. The key step in the process is the preparation of ciscyclopropane- 1, 2-dicarboxylic acid from a mixture of cis- and trans- isomers by the formation of cyclic acidic anhydride. The whole process and all of the procedures are economical, industrially reliable and easily scaled up.

Keywords: cis-cyclopropanediamine dihydrochloride, Curtius rearrangement, scale-up preparation.