Author(s): Jinlian Wei, Yingrui Yang, Mengchen Lu, Lili Xu, Fang Liu, Zhenwei Yuan, Qichao Bao, Zhengyu Jiang, Xiaoli Xu, Xiaoke Guo, Xiaojin Zhang, Qidong You and Haopeng Sun
Page: [174 - 189] Pages: 16
* (Excluding Mailing and Handling)
p53 protein is a prominent tumor suppressor to induce cell cycle arrest, apoptosis and senescence, which attracts significant interest to cancer treatment. Therefore, it would be particularly important to restore the wild–type p53 that retains latent functions in the approximately 50% of tumors. MDM2 (murine double minute 2), the principal cellular antagonist of p53, has long been believed to suppress p53 activity through two main mechanisms: promoting degradation via its E3 ligase activity and masking p53 transcriptional activation by direct binding. Targeting MDM2 E3 ligase activity is becoming a potential antitumor strategy resulting from MDM2’s decisive role in controlling the fate of p53: p53 is going to degradation when entrapped into MDM2-mediated ubiquitination, where p53 can escape by abrogating MDM2 E3 ligase activity using regulators. The intensive focus on regulating MDM2 ubiquitin E3 ligase activity has led to the rapid progress of its inhibitors, which may be possible to help p53 escape from degradation and restore its function to control tumor growth. This review summarizes the current inhibitors of MDM2 E3 ligase in cancer therapy based on the understanding the regulation of MDM2 E3 ubiquitin ligase activity, including post-translational modification, interactions between MDM2 and its cofactors, and regulation of MDM2 stability.
Keywords: Antitumor strategy, degradation, E3 ligase activity, MDM2, p53, ubiquitination.
1 x Application (59.93%) | 217ms |
1 x Booting (40.07%) | 145ms |
Backtrace |
|
INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('316636415','',1,1737783015,1737783015)
ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1737783015
Backtrace |
|
INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('316636415','/article/70178',1,1737783015,1737783015)
Backtrace |
|
(select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316636415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316636415) limit 1
Bindings |
|
Backtrace |
|
SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year,
a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator,
a.last_page, i.publication_date, a.file_name,
a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name,
a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for,
(CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle,
v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title
FROM article a
LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id
LEFT JOIN journal_section js ON a.js_id = js.js_id
LEFT JOIN article_type at ON a.art_type = at.art_type_id
LEFT JOIN issue i ON a.issue_id = i.issue_id
LEFT JOIN month m ON m.id = i.month_id
LEFT JOIN volume v ON v.volume_id = a.volume_id
INNER JOIN year y ON y.id = v.year_id
INNER JOIN journal j ON j.journal_id = a.journal_id
INNER JOIN publisher p ON p.publisher_id = j.publisher_id
WHERE a.article_id=70178
Backtrace |
|
select * from `journal` where `journal_id` = 1 limit 1
Bindings |
|
Backtrace |
|
select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword,
j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=1) and sj.journal_id!=1 group by `j`.`nid`) as `aggregate_table`
Backtrace |
|
select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword,
j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=1) and sj.journal_id!=1 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
Backtrace |
|
select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id,
v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id
FROM subject_journal
WHERE journal_id=1) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
Backtrace |
|
select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id,
v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id
FROM subject_journal
WHERE journal_id=1) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
Backtrace |
|
select * from `keywords` where `article_id` = '70178'
Bindings |
|
Backtrace |
|
select * from `article_citation` where `article_id` = '70178'
Bindings |
|
Backtrace |
|
select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors,
CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs , `au`.*, (GROUP_CONCAT(TRIM(BOTH ', ' FROM
CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),'')))
SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM
CONCAT(ifnull(concat(af.web_view,','),'')))
SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '70178' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
Bindings |
|
Backtrace |
|
select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
Bindings |
|
Backtrace |
|
select `subtitle` from `journal` where `continues_publication_journal` = 1
Bindings |
|
Backtrace |
|
Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j
join volume v on j.journal_id = v.journal_id
join issue i on v.volume_id = i.volume_id
join article a on a.issue_id = i.issue_id
join year y on v.year_id = y.id
where j.journal_id = 1 and i.is_uploaded = 1
order by v.volume_name+0 desc, i.title+0 desc limit 1
Backtrace |
|
select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id,
a.issue_id,a.title,first_page, last_page,
page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name,
a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 1 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`last_modified` desc
Backtrace |
|
select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id,
a.issue_id,a.title,first_page, last_page,
page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name,
a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 1 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`last_modified` desc
Backtrace |
|
select pdf, html, epub, prc from `article_metrics` where `article_id` = 70178 limit 1
Bindings |
|
Backtrace |
|
select * from content_by_diseases
where content_id = 70178 and content_type = 'article' order by status desc limit 1
Backtrace |
|
select a.nid article_nid,a.title article_title,j.title journal_title from content_by_diseases cd
inner join article a on a.article_id=cd.content_id
inner join journal j on j.journal_id=a.journal_id
where cd.pid = 16 and cd.sub_disease_id = 439 and content_id!=70178 and cd.content_type = 'article' order by rand()
limit 20
Backtrace |
|
select * from `node_meta` where `nid` = 134710 limit 1
Bindings |
|
Backtrace |
|
select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
Bindings |
|
Backtrace |
|
select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'ACAMC' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
Bindings |
|
Backtrace |
|
select count(*) as total_count, content_type_access_id as access_type from journal_access
where content_type_id = '70178' and content_type = 'a'
and
(
(from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or
(from_date is null and to_date is null and perpetual= 1)
)
Backtrace |
|
select count(*) as total_count, content_type_access_id as access_type from journal_access
where content_type_id = '6739' and content_type = 'i'
and
(
(from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or
(from_date is null and to_date is null and perpetual= 1)
)
Backtrace |
|
select count(*) as total_count, content_type_access_id as access_type from journal_access
where content_type_id = '1760' and content_type = 'v'
and
(
(from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or
(from_date is null and to_date is null and perpetual= 1)
)
Backtrace |
|
(select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text,
CASE j.type WHEN 111 THEN true ELSE false END as terms_popup,
"S" as content_download_type,
null as restricted_user_access_key,
null as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316636415 and j.to_ip >=316636415 )) and ((j.from_date <= 1737783015 and j.to_date >= 1737783015 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1760) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text,
false as terms_popup,
"S" as content_download_type,
null as restricted_user_access_key,
null as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316636415 and j.to_ip >=316636415 )) and ((j.from_date <= 1737783015 and j.to_date >= 1737783015 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1760) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text,
false as terms_popup,
"R" as content_download_type,
j.uc_id as restricted_user_access_key,
"v" as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316636415 and j.to_ip >=316636415 )) and ((j.from_date <= 1737783015 and j.to_date >= 1737783015 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1760)
Backtrace |
|
(select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text,
CASE j.type WHEN 111 THEN true ELSE false END as terms_popup,
"S" as content_download_type,
null as restricted_user_access_key,
null as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316636415 and j.to_ip >=316636415 )) and ((j.from_date <= 1737783015 and j.to_date >= 1737783015 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 6739) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text,
false as terms_popup,
"S" as content_download_type,
null as restricted_user_access_key,
null as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316636415 and j.to_ip >=316636415 )) and ((j.from_date <= 1737783015 and j.to_date >= 1737783015 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 6739) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text,
false as terms_popup,
"R" as content_download_type,
j.uc_id as restricted_user_access_key,
"v" as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316636415 and j.to_ip >=316636415 )) and ((j.from_date <= 1737783015 and j.to_date >= 1737783015 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 6739)
Backtrace |
|
(select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text,
CASE j.type WHEN 111 THEN true ELSE false END as terms_popup,
"S" as content_download_type,
null as restricted_user_access_key,
null as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316636415 and j.to_ip >=316636415 )) and ((j.from_date <= 1737783015 and j.to_date >= 1737783015 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 70178) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text,
false as terms_popup,
"S" as content_download_type,
null as restricted_user_access_key,
null as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316636415 and j.to_ip >=316636415 )) and ((j.from_date <= 1737783015 and j.to_date >= 1737783015 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 70178) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text,
false as terms_popup,
"R" as content_download_type,
j.uc_id as restricted_user_access_key,
"v" as restricted_user_access_type,
CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316636415 and j.to_ip >=316636415 )) and ((j.from_date <= 1737783015 and j.to_date >= 1737783015 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 70178)
Backtrace |
|
select * from `article` where `first_page` < '174' and is_uploaded = 1 and issue_id = 6739 order by cast(first_page as SIGNED) desc limit 1
Bindings |
|
Backtrace |
|
select * from `article` where `last_page` > '189' and is_uploaded = 1 and issue_id = 6739 order by cast(first_page as SIGNED) asc limit 1
Bindings |
|
Backtrace |
|
select `language_id` from `multilanguage` where `short_code` = 'en'
Bindings |
|
Backtrace |
|
select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
Bindings |
|
Backtrace |
|
select `id` from `multilanguage_article` where `article_id` = 70178 limit 1
Bindings |
|
Backtrace |
|
select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 1 and `b`.`banner_from_date` <= 1737783015 and `b`.`banner_to_date` >= 1737783015 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
Bindings |
|
Backtrace |
|
select count(*) as aggregate from `uc_cart_products` where cart_id='8fe69c5a4038209f6d4039ec10956f20'
Backtrace |
|
200
[]
[]
0 of 0array:16 [▼ "x-https" => array:1 [▶ 0 => "1" ] "host" => array:1 [▶ 0 => "beta.benthamscience.com" ] "priority" => array:1 [▶ 0 => "u=0, i" ] "accept-encoding" => array:1 [▶ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [▶ 0 => "document" ] "sec-fetch-user" => array:1 [▶ 0 => "?1" ] "sec-fetch-mode" => array:1 [▶ 0 => "navigate" ] "sec-fetch-site" => array:1 [▶ 0 => "none" ] "accept" => array:1 [▶ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [▶ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [▶ 0 => "1" ] "sec-ch-ua-platform" => array:1 [▶ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [▶ 0 => "?0" ] "sec-ch-ua" => array:1 [▶ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [▶ 0 => "no-cache" ] "pragma" => array:1 [▶ 0 => "no-cache" ] ]
[]
0 of 0array:5 [▼ "content-type" => array:1 [▶ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [▶ 0 => "no-cache, private" ] "date" => array:1 [▶ 0 => "Sat, 25 Jan 2025 05:30:15 GMT" ] "set-cookie" => array:2 [▶ 0 => "XSRF-TOKEN=eyJpdiI6IlJ2MFZIelVGdnJ0MEhocldoMC85UXc9PSIsInZhbHVlIjoiQjFCS0JVRjFRdDBGaGx2TnVsZjU2QS9vVHpqUFhjdG5PR1dyTlRrWjZGT2w1QVB3REc1RmhaaWVlUlM3eXBiWnAxMVorSjFQMFoxaEZLRStaNWFGMXFyQS9iWSsxVzZjR1VIa1Y2dWtaa3NGcW1zVktsVEI5QnpMZjNjTWJXR3AiLCJtYWMiOiIzOWVjMzZjNTdmYjNkZDM0MmM3ZDEwMmU2MWQ2ZDU0MjFiMmI1MWI5NTZiYzc0MTQ0NmViYjdmYjRmNDA0ZjQ0IiwidGFnIjoiIn0%3D; expires=Mon, 27 Jan 2025 17:30:15 GMT; Max-Age=216000; path=/; secure; samesite=strict ◀XSRF-TOKEN=eyJpdiI6IlJ2MFZIelVGdnJ0MEhocldoMC85UXc9PSIsInZhbHVlIjoiQjFCS0JVRjFRdDBGaGx2TnVsZjU2QS9vVHpqUFhjdG5PR1dyTlRrWjZGT2w1QVB3REc1RmhaaWVlUlM3eXBiWnAxMVorS ▶" 1 => "eurekaselectnew_session=eyJpdiI6IlpDeWdzdUtTQkloNEQ5RUF5T05rRnc9PSIsInZhbHVlIjoia01FbFNRa05lV09TTWQyZERlNStHSzNNSzBVcWk3amNLcnV4czNCRFVCRVVZSW5oMWNoMmRaeENwRGY3Z3hiOTFzK1F2YW52V2JpbUxONEVzM3JEdWxEL1lHSjh1K2xEbDRNNUdoWTZxck9VOWNFVW1XbDVJTjFQVWpDZWZEMXciLCJtYWMiOiI4OWYzNzU4NTFhOTc4ODdkOTgzNzIxNjdjNmYzZDY5NTM3MDI5ZDdlZGUxMTIzNDlmY2YwN2FlZDBkNmZkYzA4IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=strict ◀eurekaselectnew_session=eyJpdiI6IlpDeWdzdUtTQkloNEQ5RUF5T05rRnc9PSIsInZhbHVlIjoia01FbFNRa05lV09TTWQyZERlNStHSzNNSzBVcWk3amNLcnV4czNCRFVCRVVZSW5oMWNoMmRaeENwRGY3 ▶" ] "Set-Cookie" => array:2 [▶ 0 => "XSRF-TOKEN=eyJpdiI6IlJ2MFZIelVGdnJ0MEhocldoMC85UXc9PSIsInZhbHVlIjoiQjFCS0JVRjFRdDBGaGx2TnVsZjU2QS9vVHpqUFhjdG5PR1dyTlRrWjZGT2w1QVB3REc1RmhaaWVlUlM3eXBiWnAxMVorSjFQMFoxaEZLRStaNWFGMXFyQS9iWSsxVzZjR1VIa1Y2dWtaa3NGcW1zVktsVEI5QnpMZjNjTWJXR3AiLCJtYWMiOiIzOWVjMzZjNTdmYjNkZDM0MmM3ZDEwMmU2MWQ2ZDU0MjFiMmI1MWI5NTZiYzc0MTQ0NmViYjdmYjRmNDA0ZjQ0IiwidGFnIjoiIn0%3D; expires=Mon, 27-Jan-2025 17:30:15 GMT; path=/; secure ◀XSRF-TOKEN=eyJpdiI6IlJ2MFZIelVGdnJ0MEhocldoMC85UXc9PSIsInZhbHVlIjoiQjFCS0JVRjFRdDBGaGx2TnVsZjU2QS9vVHpqUFhjdG5PR1dyTlRrWjZGT2w1QVB3REc1RmhaaWVlUlM3eXBiWnAxMVorS ▶" 1 => "eurekaselectnew_session=eyJpdiI6IlpDeWdzdUtTQkloNEQ5RUF5T05rRnc9PSIsInZhbHVlIjoia01FbFNRa05lV09TTWQyZERlNStHSzNNSzBVcWk3amNLcnV4czNCRFVCRVVZSW5oMWNoMmRaeENwRGY3Z3hiOTFzK1F2YW52V2JpbUxONEVzM3JEdWxEL1lHSjh1K2xEbDRNNUdoWTZxck9VOWNFVW1XbDVJTjFQVWpDZWZEMXciLCJtYWMiOiI4OWYzNzU4NTFhOTc4ODdkOTgzNzIxNjdjNmYzZDY5NTM3MDI5ZDdlZGUxMTIzNDlmY2YwN2FlZDBkNmZkYzA4IiwidGFnIjoiIn0%3D; path=/; secure; httponly ◀eurekaselectnew_session=eyJpdiI6IlpDeWdzdUtTQkloNEQ5RUF5T05rRnc9PSIsInZhbHVlIjoia01FbFNRa05lV09TTWQyZERlNStHSzNNSzBVcWk3amNLcnV4czNCRFVCRVVZSW5oMWNoMmRaeENwRGY3 ▶" ] ]
0 of 0array:5 [▼ "_token" => "EQsZ6awMsAaGZ85q3kLQrnAS0DdHh6WEJnTpTYun" "uc_cart_id" => "8fe69c5a4038209f6d4039ec10956f20" "_previous" => array:1 [▶ "url" => "https://beta.benthamscience.com/article/70178" ] "_flash" => array:2 [▶ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]