This review reports the methods developed for the synthesis of functionalized 1,2,4-triazines bearing phosphorus-amides as donor-acceptor interactions. These methods depend on the phosphorylation or phosphoimination of side functional groups of 1,2,4-triazine to produce isolated or fused phosphorus heterocyclic systems in view of their biocidal properties.
Keywords: 1, 2, 4-Triazines, phosphorylation, phospho-imination, biocidal effects.