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Current Organic Synthesis

Author(s): Antonio C. B. Burtoloso, João V. Santiago, Barbara Bernardim and Alexánder G. Talero

DOI: 10.2174/157017941205150821153658

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Advances in the Enantioselective Metal-catalyzed N-H and O-H Insertion Reactions with Diazocarbonyl Compounds

Page: [650 - 659] Pages: 10

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Abstract

Insertion of diazocarbonyl-derived metallocarbenes into X-H bonds (X= H, C, Si, N, O, S, P, Se) has proven to be a very important method for the construction of C-X bonds in organic chemistry. This mini-review provides a brief historical background, mechanistic aspects and a summary of recent breakthroughs in the area of enantioselective metal-catalyzed N-H and O-H insertion reactions.

Keywords: Asymmetric catalysis, carbenes, diazocarbonyls, enantioselective, insertion reactions, metal catalysis.

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