Abstract

A rapid and efficient, one-pot, three-component, microwave-assisted synthesis of spiro[indoline-3,4'-quinoline] derivatives has been accomplished through three-component Knoevenagel/ Michael addition reaction of isatin, malononitrile and various amine derivative in very good to outstanding yields under CuCl₂ catalyst. The main benefits of this protocol are simple work-up, trivial and eco-friendly reaction conditions. Biological characterization, including antibacterial was also evaluated.

Keywords: CuCl₂, isatin, microwave-assisted synthesis, multi-component reactions, spiro compound.