Abstract

The first part of the review brings forth the detailed synthesis of the known camphor-derived organocatalysts. Most synthetic steps are operationally simple, enabling the preparation of the corresponding catalysts on a larger scale. Frequently, the bicyclic framework of camphor is connected with a proline-derivative through a suitable spacer, which enables the preparation of a library of organocatalysts needed for the fine-tuning of a selected stereoselective transformation. The second part of the review focuses on the application of camphor-derived organocatalysts in various fields of asymmetric organocatalysis. Catalytic reactions are often conducted under mild reaction conditions giving the corresponding products in good to excellent stereoselectivities.

Keywords: Camphor, ketopinic acid, camphorsulfonic acid, proline, pyrrolidine, asymmetric organocatalysis, N-heterocyclic carbene.

Graphical Abstract