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Letters in Organic Chemistry

Author(s): Takuma Yoshida, Lei Wang, Shiori Nakagawa, Zetryana Puteri Tachrim, Yasuko Sakihama, Yasuyuki Hashidoko and Makoto Hashimoto

DOI: 10.2174/1570178612666150629181357

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Synthesis of Cross-linkable 2,5-Diketopiperazine Derivatives

Page: [544 - 548] Pages: 5

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Abstract

Synthesis of cross-linkable diketopiperadine derivatives is described. Cross-linkable aamino acid methyl esters were subjected to peptide synthesis with Boc-protected glycine or L-tyrosine. No protection of cross-linkable functional groups (catechol and phenylazide) is necessary for the construction of diketopiperazine skeleton.

Keywords: Cross-link, cyclic dipeptide, diketopiperazine, DOPA, phenylazide, photoaffinity label.

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