Abstract

The multicomponent reactions involving the use of environmentally benign solvents, and non-toxic, and recyclable organocatalysts require special attention as with such significant characters, the multicomponent reactions satisfy the green chemistry’s principles to a greater extent. The environmentally benign synthetic protocols with the amalgamation of multicomponent reactions, characterized by synthetic efficiency and structural diversity with bio-relevance offered by natural products, facilitate the generation of high quality leads for drug discovery. In the present review, the significant research work relating to the L-proline catalyzed multicomponent reactions has been presented. Moreover, the reactions catalyzed by tagged L-proline or modified L-proline based organocatalysts have also been included with a view to incorporate recent research trends in L-proline organocatalysis.

Keywords: Drug discovery research, environmentally benign synthetic protocols, green chemistry, high throughput screening, L-proline, modified L-proline, multicomponent reactions, organocatalysis, organocatalyst, tagged L-proline.