Abstract

Synthetic methods for the enantioselective constructions of trifluoromethylated stereogenic centers are described. In particular, this review focuses on recent examples of catalytic enantioselective transformations with trifluoromethyl alkenes. These reactions efficiently synthesized chiral compounds with trifluoromethylated stereogenic centers.

Keywords: Trifluoromethyl group, enantioselective synthesis, chiral catalyst, conjugate addition, Diels-Alder reaction, trifluoromethyl alkenes

Graphical Abstract