Author(s): Yapuri Umanadh, Gudaparthi Omprakash and Narahari Srinivasareddy
Page: [424 - 428] Pages: 5
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A concise stereoselective total synthesis of (-) - Cephalosporolide D, an eight membered lactone ring has been derived from low cost and easily available starting material (±)-propylene epoxide. The key steps involved in this concise synthesis are Sharpless kinetic resolution, Grignard reaction and Yamaguchi macrolactonisation.
Keywords: (±)-propylene epoxide, sharpless kinetic resolution, yamaguchi macrolactonisation, stereoselective synthesis and (-) - cephalosporolide D.
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