Anti-Cancer Agents in Medicinal Chemistry

Author(s): Christine Basmadjian, Helene Malka-Mahieu and Laurent Desaubry

DOI: 10.2174/1871520615666150602092450

DownloadDownload PDF Flyer Cite As
Revision of the Synthesis and Pharmacological Activity of a Reported Translation Inhibitor

Page: [1305 - 1307] Pages: 3

  • * (Excluding Mailing and Handling)

Abstract

4EGI-1 is the prototype of a novel class of anticancer agents targeting translation. Patented drug-like analogue 1 was synthesized and examined for inhibition of translation and cytotoxicity in cancer cells. Unexpectedly, 1 was found inactive in both assays.

Keywords: Cancer, eIF4E, metastatic melanoma, mRNA translation, protein synthesis, thiazoles.

Graphical Abstract