Abstract

Protein ADP-ribosylation is an important posttranslational modification that plays versatile roles in multiple biological processes. ADP-ribosylation is catalyzed by a group of enzymes known as ADP-ribosyltransferases (ARTs). Using nicotinamide adenine dinucleotide (NAD⁺) as the donor, ARTs covalently link single or multiple ADP-ribose moieties from NAD⁺ to the substrates, forming mono ADP-ribosylation or poly ADP-ribosylation (PARylation). Novel functions of ARTs and ADPribosylation have been revealed over the past few years. Here we summarize the current knowledge on ARTs and PARylation.

Keywords: ADP-ribosylation, ADP-ribosyltransferase, ART, ARTD, PAR, PARylation.