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Letters in Organic Chemistry

Author(s): Kamlesh S. Vadagaonkar, Hanuman P. Kalmode, Kaliyappan Murugan and Atul C. Chaskar

DOI: 10.2174/1570178612666150425000023

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Metal-free Synthesis of 2,4,6-Trisubstituted Pyrimidines using α,β-Unsaturated Ketones and Benzamidine via Tandem Annulation-Oxidation Pathway

Page: [447 - 458] Pages: 12

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Abstract

A tandem metal-free synthesis of partly and fully substituted pyrimidines has been accomplished from α,β-unsaturated ketones and benzamidine in presence of triethyl amine. The reaction proceeds via [3+3] annulation-oxidation sequence and the protocol has been found successful for the synthesis of a wide range of pyrimidine derivatives.

Keywords: Benzamidine, Metal-free synthesis, Triethyl amine, Tandem [3+3] annulation-oxidation pathway, α, β-Unsaturated ketones.

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