Author(s): Concepcion Alonso, Maria Fuertes, Maria Gonzalez, Alicia Rodriguez-Gascon, Gloria Rubiales and Francisco Palacios
Page: [2722 - 2728] Pages: 7
* (Excluding Mailing and Handling)
The synthesis of a variety of phenyl- and indeno-1,5-naphthyridine derivatives as new substrates with anticancer activity is described. Several of the prepared products were addressed to in vitro anticancer screening which indicated that some of them exhibited inhibitory effect of Top1 and antiproliferative activity against human colon cancer cells (COLO 205).
Keywords: Camptothecin, cytotoxicity, heterocycles, inhibitory activity, naphthyridines, topoisomerase I.
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