Abstract

A series of new chiral bifunctional Ferrocenylphosphines was designed, synthesized and applied for the asymmetric aza-Morita-Baylis-Hillman reaction of N-sulfonated imines with methyl vinyl ketone (MVK). The reaction proceeded under mild conditions to afford the desired aza-MBH adducts in moderate to high yields with up to 56% ee value.

Keywords: aza-MBH adducts, aza-Morita-Baylis-Hillman reaction, chiral bifunctional ferrocenylphosphines, organocatalyst.