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Current Organic Synthesis

Author(s): Chelliah Selvam and Francine Acher

DOI: 10.2174/1570179411999141106101117

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Expeditious Synthesis of bis-(α-hydroxyalkyl)phosphinic Acid Using N-O-bis (trimethylsilyl)acetamide (BSA)

Page: [168 - 172] Pages: 5

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Abstract

Highly efficient, synthetic procedure for bis-(α-hydroxyalkyl)phosphinic acids is described using N-O-bis( trimethylsilyl)acetamide (BSA). Various substituted aldehydes undergo the addition of hypophosphorous acid in good to excellent yields. Operational simplicity, high yield and shorter reaction time are the key features associated with this protocol.

Keywords: α-hydroxyphosphinic acid, Hypophosphorous acid, N-O-bis(trimethylsilyl)acetamide, Phosphinic acids, P-alkylation.

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