Abstract

The dopamine D₂ receptor radiotracer [¹¹C]Raclopride is used extensively in clinical and preclinical imaging. Currently, a wide range of methods to produce [¹¹C]Raclopride have been developed using traditional vessel reactions as well as cartridge or captive solvent.

This work reports the optimisation of the production of [¹¹C]Raclopride using a Synthra GPextent, comparing various methods. With optimised conditions, we were able to obtain 4±2% (ndc) yield of [¹¹C]Raclopride (100 GBq [¹¹C]CO₂, n = 42) in 25 min. The radiochemical purity was >95% with specific activities of 135±41 MBq/nmol at end of synthesis.

Keywords: 11Carbon, GPextent, optimization, raclopride.