Current Drug Delivery

Author(s): Ken D. Johnstone, Manuela Dieckelmann, Michael P. Jennings, Istvan Toth and Joanne T. Blanchfield

DOI: 10.2174/1567201054367977

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Chemo-Enzymatic Synthesis of a Trisaccharide-Linked Peptide Aimed at Improved Drug-Delivery

Page: [215 - 222] Pages: 8

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Abstract

The glycosyltransferase enzyme LgtA, derived from the bacterial pathogen Neisseria meningitidis, was utilised in the chemo-enzymatic synthesis of a trisaccharide-linked endomorphin peptide drug candidate.

Keywords: glycosyltransferase, oligosaccharide, chemo-enzymatic, glycopeptide, solid-phase synthesis, endomorphin, peptide drug delivery, drug targeting