Microwave-mediated Regiospecific Synthesis of Some Novel Annulated Spiro[indoline-3,1`-indolizin]-2-ones

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Abstract

A library of hitherto unknown functionalized and annulated spiro[indoline-3,1`-indolizin]-2-one derivatives incorporating thiophene moiety has been synthesized under conventional and microwave irradiation conditions. The structures, regio and diastereoselectivity of the synthesized cycloadducts have been confirmed using different analytical and spectral tools.

Keywords: 2d NMR, microwave irradiation, regioselectivity, spiro[indoline-3, 1`-indolizin]-2-one derivatives.

Graphical Abstract