Abstract

Chronic wounds and ulcers denote a grave ubiquitous complication, and the bacterial contagions existing in such lesions further impede their successful and swift healing. Wound dressings currently used are far from being ideal. Consequently, there is a demand to design bio responsive material, which not only sets a mechanical aid but also cutbacks microbial load and modulates the complex events of tissue regeneration and morphogenesis by recruiting cells to the wound site. In the current scrutiny, PLGA/Gelatin 70:30 nanofibrous scaffolds laden with gentamicin were prepared by electrospinning. The compatibility between the constituents of the nanofibrous scaffolds was determined by Fourier Transform Infrared Spectroscopy, and the physical state of the constituents was studied by Thermogravimetric analysis. Porosity and swelling index were also calculated and the outcomes revealed a remarkable resemblance to the extracellular matrix. The in vitro drug release studies manifested a constant drug release deprived of burst effect designating that the drug was homogeneously dispersed in the scaffold matrix and there was no significant amount of drug adsorbed onto the surface. This study demonstrated that gentamicin loaded PLGA/Gelatin 70:30 nanofibrous scaffolds have potential to be used as a promising wound dressing material to prevent bacterial infection at the wound site.

Keywords: Bioresponsive, electrospinning, nanofibrous scaffolds, tissue regeneration, wound dressings.

Graphical Abstract