Abstract

Various biomedical applications that use Fe₃O₄ magnetic nanoparticles, both for diagnostic or/and therapy have been described. This review summarizes the most common synthesis methods for Fe₃O₄ nanoparticles, recently used for developing applications which improve the cancer treatment. We emphasize the tumor targeting possibilities for such systems, the magnetic hyperthermia and controlled delivery of anti-tumor, focusing on Fe₃O₄-based systems for osteosarcoma treatment using Doxorubicin as chemotherapeutic agent.

Keywords: Cancer therapy, drug delivery systems, Fe₃O₄, hyperthermia, magnetite, nanomedicine, targeting.

Graphical Abstract