Abstract

A novel and flexible synthetic approach to enureas is described. This convenient method has been developed for the Pd-catalyzed C-N coupling reaction of alkenyl nonaflates with a variety of ureas. A ferrocene based phosphine ligand, Joshiphos appeared noticeable as the most dynamic catalyst and K₃PO₄ in t-BuOH was established to be the most favorable base-solvent combination for the reaction. This catalyst system displayed amazing functional group tolerance and assigned quick synthesis of the entire series of enureas in excellent yields.

Keywords: Alkenyl nonaflate, aryl urea, Buchwald-Hartwig reaction, enurea, microwave assisted synthesis, Palladium catalyzed C-N coupling, urea.

Graphical Abstract