Letters in Organic Chemistry

Author(s): Samereh Seyfi, Faramarz Rostami-Charati, Zinatossadat Hossaini and Mohammad R. Zardoost

DOI: 10.2174/157017861106140413171933

Synthesis of 4-oxo-2,5-cyclopentadiene Using Multi-component Reactions of Primary Amines and Electron Deficient Acetylenic Compounds with Triphenylphosphine in Water

Page: [409 - 412] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

A water-accelerated multicomponent synthesis of organic target molecules has been used as a key method for the preparation of cyclopentadiene derivatives. The three-component condensation reactions of primary amines with alkyl propiolates in the presence of triphenylphosphine in water at 80 °C are developed as efficient and clean green synthetic procedures for the high-yielding preparation of 4-oxo-2,5-cyclopentadiene-1,2-dicarboxylate derivatives.

Keywords: Cyclopentadiene, primary amines, triphenylphosphine, alkyl propiolates, multi-component reaction.

Graphical Abstract