Abstract

Two series of novel 1-(4-substitutedbenzoyl)-3-((2-oxoimidazolin-1-yl)methyl)-1H-pyrazol-5(4H)-one, 1- methyl-3-((1-(4-substitutedbenzoyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl)methyl)urea,1-((1-(4-substitutedbenzoyl)-5-oxo- 4,5-dihydro-1H-pyrazol-3-yl)methyl) thio urea and 1-((1-(4-substitutedbenzoyl)-5-oxo-4,5-dihydro-1H-pyrazol-3- yl)methyl)-3-phenyl thiourea were synthesized and characterized by IR, mass, ¹HNMR spectroscopic techniques. The synthesized compounds were evaluated for anticonvulsant activity by using maximal electroshock seizure (MES) model. Among the newly synthesized compounds, most of the compounds showed significant activity and 1C₂ emerged as the most active analogue.

Keywords: Anticonvulsant, convulsion, MES, pharmacophore, pyrazol-5-one.