A Xylose-Catalyzed One-Pot Four-Component Domino Protocol for the Facile Synthesis of Highly Substituted Dihydropyrrol-2-ones

Seyed   Sajad   Sajadikhah; Malek   Taher   Maghsoodlou; Nourallah      Hazeri; Maryam      Moein; Mahmoud      Norouzi; Sajad      Mohamadian-Souri

Letters in Organic Chemistry

Author(s): Seyed Sajad Sajadikhah, Malek Taher Maghsoodlou, Nourallah Hazeri, Maryam Moein, Mahmoud Norouzi and Sajad Mohamadian-Souri

DOI: 10.2174/1570178611999140221164131

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A Xylose-Catalyzed One-Pot Four-Component Domino Protocol for the Facile Synthesis of Highly Substituted Dihydropyrrol-2-ones

Page: [268 - 272] Pages: 5

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Abstract

Xylose was found as a natural, cheap and efficient organocatalyst for the one-pot synthesis of substituted dihydropyrrol- 2-ones via a four-component domino reaction between amines, dialkyl acetylenedicarboxilates and formaldehyde. This protocol includes some important aspects like mild reaction conditions, good yields, short reaction times, affordable procedure, simple work-up and lack of need for column chromatography.

Keywords: Dihydropyrrol-2-one, heterocycle, xylose, organocatalyst, multi-component reaction.

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