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Current Topics in Medicinal Chemistry

Author(s): Alla B. Salmina, Olga Lopatina, Natalia V. Kuvacheva and Haruhiro Higashida

DOI: 10.2174/15680266113136660211

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Integrative Neurochemistry and Neurobiology of Social Recognition and Behavior Analyzed with Respect to CD38-Dependent Brain Oxytocin Secretion

Page: [2965 - 2977] Pages: 13

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Abstract

This review summarizes the literature and our own data regarding the role of NAD+-glycohydrolase/CD38- controlled molecular mechanisms of hypothalamic and pituitary oxytocin secretion in social behavior regulation. Current approaches to the modulation of both CD38 expression and brain cell activity that represent prospective treatments for disorders associated with altered social behavior are discussed.

Keywords: CD38, oxytocin, social behavior.