Abstract

In this review, we have presented the controlled synthesis of Fe-based metal and oxide nanoparticles with large size by chemical methods. The issues of the size, shape and morphology of Fe nanoparticles are discussed in the certain ranges of practical applications in biology and medicine. The homogeneous nanosystems of Fe-based metal and oxide nanoparticles with various sizes and shapes from the nano-to-micro ranges can be used in order to meet the demands of the treatments of dangerous tumors and cancers through magnetic hyperthermia and magnetic resonance imaging (MRI). In this context, the polyhedral Fe-based metal and oxide nanoparticles having large size in the ranges from 1000 nm to 5000 nm can be potentially used in magnetic hyperthermia and MRI in the innovative drug delivery, diagnosis, treatment, and therapy of tumor and cancer diseases because of their very high bio-adaptability. We have suggested that high stability and durability of Fe-based metal and oxide nanoparticles are very crucial to recent magnetic hyperthermia and MRI technology. The roles of various Fe-based nanostructures are focused in biomedical applications of tumors and cancers diagnostics, targeted drug delivery, and magnetic hyperthermia. Finally, Fe-based, α-, β- and γ-Fe₂O₃, and Fe₃O₄-based nanoparticles are shortly discussed in various potential applications in catalysis, biology, and medicine.

Keywords: Biology and medicine, biomedical applications, Fe₃O₄-based nanoparticles, Fe-based bimetallic nanoparticles, Febased core shell nanoparticles, Fe-based mixture nanoparticles, Fe-based nanoparticles, Fe-based nanostructures, hyperthermia, Iron metal, magnetic nanoparticles, magnetic properties, magnetic resonance imaging (MRI), nano fluids, α- and γ-Fe₂O₃ nanoparticles.