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Anti-Cancer Agents in Medicinal Chemistry

Author(s): Vikas Kumar, Akshay Kumar, Vommina V. Sureshbabu and Swapandeep S. Chimni

DOI: 10.2174/18715206113136660368

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Synthesis and Stereochemistry-Activity Relationship of Chiral Thiourea Derivatives as Potential Anticancer Agents

Page: [910 - 920] Pages: 11

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Abstract

Synthesis of new chiral thiourea derivatives (27 examples) as anticancer agents has been described. Three compound 7d (NSC code 761448/1), 7e1 (NSC code 767161/1), and 7e3 (NSC code 767160/1) were found to exhibit higher anticancer activity than 5-fluorouracil against Colon cancer, Melanoma, Ovarian cancer, and Breast cancer subpanels. The effect of stereochemistry of amino acid residues on the tumor growth inhibitory activity has also been studied.

Keywords: Amino acid residues, anticancer therapy, thiourea derivatives.