Abstract

Supported reagents and scavengers have become key tools for the synthesis of biologically important molecular entities. The complexity of the target molecules attainable and the synthetic flexibility afforded by these systems now rivals any solution phase approach whilst offering the added advantage of rapid purification and work-up. This short review highlights the application of these immobilized reagents to the preparation of alkaloid natural products.

Keywords: organic synthesis, purification techniques, reagent immobilization, amaryllidaceae alkaloids, nornicotine, polymer-supported carbonate, trifluoroacetamide