Abstract

A high efficient and environmentally friendly procedure for the production of bis thiazolidinones has been developed. This synthetic approach involves the simple condensation of an appropriate dialdehyde and N,N'-diarylthioureas with chloroacetyl chloride in eutectic salts as a promoter and solvent at 80 ^°C. All products were obtained in good to excellent yields. Structures of these compounds were established on the basis of IR, ¹H-NMR, ¹³C-NMR and by elemental analysis.

Keywords: Bis thiazolidinone heterocycles, choline chloride, green chemistry, ionic liquids, multicomponent reactions, one-pot synthesis.