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Letters in Organic Chemistry

Author(s): Lingxia Pan, Lin Huang and Chunsong Xie

DOI: 10.2174/15701786113109990049

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Synthesis of Methylenebisamides by TFA-Promoted Reactions of Nitriles and DMSO

Page: [770 - 773] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

Under TFA promoted conditions, aryl and 2-pyridyl nitriles can react with DMSO, affording methylenebisamides in moderate to good yields. While the electron-donating groups give good yields, the electron-withdrawing groups provide lower yields.

Keywords: Methylenebisamide, nitrile, DMSO.