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Current Organic Synthesis

Author(s): Huwaida M.E. Hassaneen and Ismail A. Abdelhamid

DOI: 10.2174/15701794113109990065

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One-Pot Synthesis of 5-Unsubstituted-6-Aroyl[1,2,4]triazolo[1,5-a]pyrimidine Utilizing Biginelli-Like Multicomponent Reaction of Enaminones with 3-Amino-1,2,4- triazole as the Urea Component

Page: [974 - 976] Pages: 3

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Abstract

A novel and facile Biginelli-like assembly employing enaminones, aldehydes and 3-amino-1,2,4-triazole has been developed, which provides a novel synthesis of new 5-unsubstituted-6-aroyl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives.

Keywords: 3-amino-1, 2, 4-triazole, enamines, Biginelli-like, 6-Aroyl-[1, 2, 4]triazolo[1, 5-a]pyrimidine, pyrimidine-2-thione, 4-aryl-7-thioxo- 3, 4, 7, 8-tetrahydropyrimido[4, 5-d]pyrimidine-2, 5(1H, 6H)-dione.