Abstract

The focus of the review is on the formation of multiple bonds by palladium catalyzed C-H activation and functionalization. These include alkanylation, alkenylation, arylations, annulations, domino, cascade reaction, coupling and synthesis of spiro compounds. The non-synchronous formation of new carbon-carbon and carbon-heteroatom (N, O) bonds for the construction of various heterocycles is also discussed.

Keywords: C-H activation, Non synchronous Multiple-bond formation, Palladium catalysis, Coupling reactions, Domino reactions, Heterocycles.