Current Organic Chemistry

Author(s): Xavier Bugaut, Damien Bonne, Yoann Coquerel, Jean Rodriguez and Thierry Constantieux

DOI: 10.2174/13852728113179990090

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Michael Addition-initiated Sequential Reactions from 1,3-dicarbonyls for the Synthesis of Polycyclic Heterocycles

Page: [1920 - 1928] Pages: 9

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Abstract

This review aims to highlight the most significant recent developments on synthetic strategies involving consecutive, domino and multicomponent reactions featuring a Michael addition-initiating step for the synthesis of polycyclic heterocycles from 1,3- dicarbonyls. These original sequences constitute more efficient and eco-compatible alternatives to known synthetic approaches to heterocyclic compounds allowing for an even faster and highly desirable generation of molecular diversity and complexity.

Keywords: Consecutive reactions, Domino reactions, Multicomponent reactions, Michael addition, Polycyclic heterocycles, 1, 3-Dicarbonyl compounds.