Author(s): Orazio A. Attanasi, Luca Bianchi, Maurizio D’Auria, Fabio Mantellini and Rocco Racioppi
Page: [631 - 639] Pages: 9
* (Excluding Mailing and Handling)
1,2-Diaza-1,3-dienes bearing electron-withdrawing groups react with electron-poor alkenes by means of an uncommon aza- Diels-Alder reaction furnishing novel tetrahydropyridazines with high regio- and stereoselectivity. Conducting these cycloadditions in solvent free conditions under thermal conditions the reaction times are significantly reduced, the yields are improved and the stereoselectivity remained unchanged.
Keywords: 1, 2-Diaza-1, 3-dienes, Electron- poor alkenes, Aza-Diels-Alder, Solvent free conditions, DFT calculations.
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