Abstract

One-pot synthesis of 2-azetidinones has efficiently been carried out in excellent yields by treatment of imines and substituted acetic acids with 3,5-dinitrobenzoyl chloride in the presence of triethylamine. The method is remarkably convenient and pure products were obtained by simple crystallization.

Keywords: β-Lactam, 2-Azetidinone, Staudinger reaction, 3, 5-Dinitrobenzoyl chloride, Ketene, Imine.