Current Pharmaceutical Design

Author(s): Samuele De Minicis, Chris Day and Gianluca Svegliati-Baroni

DOI: 10.2174/1381612811319290006

From NAFLD to NASH and HCC: Pathogenetic Mechanisms and Therapeutic Insights

Page: [5239 - 5249] Pages: 11

  • * (Excluding Mailing and Handling)

Abstract

NAFLD is the most common liver disease worldwide but it is the potential evolution to cirrhosis and hepatocellular carcinoma (HCC) that makes NAFLD of such clinical importance. The current work provides an overview of the main mechanims and potential therapeutical insights involved in NAFLD, NASH, fibrosis and HCC progression.

Keywords: NAFLD, NASH, fibrosis, microbiota, bacterial translocation.