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Mini-Reviews in Medicinal Chemistry

Author(s): Anna Bielenica, Anna E. Koziol and Marta Struga

DOI: 10.2174/1389557511313100012

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Binding Modes of Chain Arylpiperazines to 5-HT1a, 5-HT2a and 5-HT7 Receptors

Page: [1516 - 1539] Pages: 24

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Abstract

An overview of docking models of chain arylpiperazines to different subtypes of serotonin receptors belonging to the GPCR family is presented. The theory of a ligand-receptor interaction has been briefly summarized. The review covers more than twenty models, beginning with the early models of a ligand interaction with the 5-HT1A and 5-HT2A receptor, and ending with a ligand-5-HT7 receptor docking studies.

Keywords: Docking, arylpiperazines, 5-HT1A receptor, 5-HT2A receptor, 5-HT7 receptor.