Abstract

Isoxazole is a five membered heterocyclic compound having various pharmacological actions. The new practical synthesis of isoxazole from the easily available malonadehyde tetraethyl acetal by avoiding the use of toxic reagent such as cadmium chloride under environment friendly conditions has been developed.

Keywords: Isoxazole, Malonaldehyde tetraethyl acetal, di (1, 3-dioxolan-2-yl) methane.