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Letters in Organic Chemistry

Author(s): Imene Sehout, Raouf Boulcina, Boudjemaa Boumoud, Fabienne Berree, Bertrand Carboni and Abdelmadjid Debache

DOI: 10.2174/15701786113109990014

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Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones

Page: [463 - 467] Pages: 5

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Abstract

An efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli condensation of aldehyde, ethyl acetoacetate, and urea or thiourea in the presence of a catalytic amount of ascorbic acid (5 mol %) is described. The reaction proceeded efficiently under solvent-free conditions at 80 °C to afford the desired products in moderate to good yields.

Keywords: Multicomponent reaction; one-pot synthesis; Biginelli reaction; 3, 4dihydropyrimidin-2(1H)-ones/thiones; ascorbic acid.