A new series of gem-phosphonate-phosphates bearing N-alkyl groups and aromatic substituents has been prepared by reductive cleavage of the isoxazolidine ring with metal carbonyls, using the gem-phosphonate-phosphate rearrangement.
Keywords: Apolipoprotein E, bisphosphonates, gem-phosphonate-phosphate rearrangement, isoxazolidines, ring opening, transition-metal carbonyls.