Abstract

This paper provides a literature and patent review on the research and development work contributing to the current status of microsphere generation as an application of nanofluids for drug delivery. The polymer-based microsphere plays an important role to protect protein-based drugs and to deliver the drug to the desired sites. This review covers four microfluidic systems for microsphere generation: membrane emulsification with cross flow, T-junction, hydrodynamic flow focusing and chopper. A discussion on the current state of the arts of the microfluidic systems is addressed, and opportunities for future research are acknowledged.

Keywords: MEMS, microfluidic systems, microsphere generation, nanofluids.