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Letters in Organic Chemistry

Author(s): Jairo Quiroga, Angela Valencia, Alfredo Perez, Jaime Galvez, Rodrigo Abonia and Braulio Insuasty

DOI: 10.2174/1570178611310050006

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Catalyst-free Synthesis of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine Derivatives by Aza-Diels-Alder Reaction

Page: [337 - 341] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

A series of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives was synthesized via catalyst-free bi-component and one-pot reactions of 5-aminopyrazoles, DMF-DMA (or TMOF) and N-arylmaleimides in xylene as solvent. This protocol showed advantages of milder reaction conditions, easier work-up, shorter reaction times and good yields, over other approaches tested.

Keywords: Aminopyrazoles, DMF-DMA, TMOF, maleimides, pyrazolopyrrolopyridines, Aza-Diels-Alder reaction.