A Formal [3+3] Cyclocondensation Strategy for the Synthesis of Polysubstituted Phenols by Reaction of Alkynyl Ketones with 1,3-Dicarbonyl Compounds

Jie      Li; Ruimao      Hua; Tao      Liu

Current Organic Synthesis

Author(s): Jie Li, Ruimao Hua and Tao Liu

DOI: 10.2174/1570179411310030011

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A Formal [3+3] Cyclocondensation Strategy for the Synthesis of Polysubstituted Phenols by Reaction of Alkynyl Ketones with 1,3-Dicarbonyl Compounds

Page: [486 - 491] Pages: 6

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Abstract

The cyclocondensation of alkynyl ketones with 1,3-dicarbonyl compounds in the presence of NaOH in DMF at 80 °C affording polysubstituted phenols with high atom-efficiency in moderate to good total yields is developed.

Keywords: Alkynyl ketones, cyclocondensation, 1, 3-Dicarbonyl compounds, phenols.

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