Synthesis of New Aryl(Hetaryl)-Substituted Tandospirones Under Reductive Heck Type Hydroarylations and Isoxazoline Derivatives via 1,3-Dipolar Cycloaddition Reactions with Expected Anxiolytic Activity†

Irem      Kulu; Asli      Kopruceli; Gokce      Goksu; Nuket      Ocal

Current Organic Synthesis

Author(s): Irem Kulu, Asli Kopruceli, Gokce Goksu and Nuket Ocal

DOI: 10.2174/1570179411310030010

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Synthesis of New Aryl(Hetaryl)-Substituted Tandospirones Under Reductive Heck Type Hydroarylations and Isoxazoline Derivatives via 1,3-Dipolar Cycloaddition Reactions with Expected Anxiolytic Activity†

Page: [481 - 485] Pages: 5

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Abstract

The C-C coupling of bicyclic alkene 4 with aryl and heteroaryl iodides gave under reductive Heck conditions the Caryl( hetaryl), N-[((4-pyrimidin-2-yl)piperazin-1-yl)butyl]substituted bicyclic imides 5a-f. The [3+2] cycloadditions of 4 with various nitrile oxides yielded the bridged isoxazoline derivatives 6-8 with potential biological activity.

Keywords: Antidepressant drugs, bicyclic imides, biological activity, C-C coupling, isoxazolines, palladium(II) acetate, arylpiperazine moiety.

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