Generic placeholder image

Letters in Organic Chemistry

Author(s): Rui Huang, Chunsong Xie, Lin Huang and Jinhua Liu

DOI: 10.2174/1570178611310030009

DownloadDownload PDF Flyer Cite As
A Novel Synthesis of 1,4,7,10-Tetraazacyclododecane by the Tandem Reaction of a Vinylsulfonium Salt

Page: [195 - 198] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

1,4,7,10-Tetraazacyclododecane was synthesized through 4 steps by using easily available diphenylsulfonium triflate as a key annulation reagent. The reaction condition was very mild and the yield was high. After oxidation and hydrolysis, 1,4,7,10-Tetraazacyclododecane, which had been proven to be the pivotal precursor for a wide range of MRI contrast reagents, was produced in an overall yield of 31%.

Keywords: 1, 4, 7, 10-Tetraazacyclododecane, MRI, Tandem Reaction, Vinylsulfonium