Abstract

The interventional studies with bone biopsy of the SAPHO lesions and microbiological investigation are a significant addition to a long range of publications showing an association of SAPHO with Propionibacterium acnes. Infectious agents isolated from SAPHO patients have merited special attention for many years. Their possible etiological role is supported by the pathogen isolation from different sites: anterior chest wall, spine, synovial fluid, bone tissue, and skin pustules. A range of pathogens have been found, including Staphylococcus aureus, Hemophilusparainfluenzae, actinomyces, and even Treponemapallidum. P. acnes is a much more frequent pathogen and plays a particular role. The article focus is to emphasize limited use of interventional method to verify infection ethology of SAPHO in publications last two years. Successful therapy may be really effective and eradicative on a basis of the pathogen identification.Randomized control studies are needed to confirm the effects of antibiotic therapy.

Keywords: SAPHO syndrome, interventional method, infectious ethiology, P. Acne.